ea0090p113 | Endocrine-related Cancer | ECE2023
Landwehr Laura-Sophie
, Appenzeller Silke
, Olsner Laura
, Weigand Isabel
, Sbiera Silviu
, Fassnacht Martin
, Kroiss Matthias
Introduction: Adrenocortical carcinoma (ACC) is one of the most aggressive endocrine malignancies and confers a poor prognosis in advanced stages. Effective treatments are lacking. The results of immune checkpoint inhibition were disappointing with few responders only deriving clinical benefit. For the development of novel immunotherapies such as tumor vaccines and T cell-based treatments, target identification is essential. Tumor-specific mutant neoantigens that may be recogn...